There are generally two types of one-way flow cleanrooms, namely horizontal flow and vertical flow.

In a horizontal flow system, airflow flows from one wall to another.

In a vertical flow system, airflow flows from the ceiling to the ground.

For situations where the concentration of suspended particles or microorganisms in the clean room is required to be lower, unidirectional airflow is used. Previously, this type of clean room was referred to as a "laminar flow" clean room.

Both the names of unidirectional flow and laminar flow describe the state of their airflow: the airflow flows in one direction (either vertical or horizontal) and flows through the entire space at an average velocity of typically 0.3 to 0.5 meters per second (60 to 100 feet per minute).

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